Glycogen Synthase 1 antibody (pSer645)

Catalog No. ABIN7221420

The Rabbit Polyclonal anti-Glycogen Synthase 1 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect Glycogen Synthase 1 in samples from Human, Mouse and Rat.

Quick Overview for Glycogen Synthase 1 antibody (pSer645) (ABIN7221420)

Target: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glycogen Synthase 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Glycogen Synthase 1 Antibody

Binding Specificity: pSer645

Purpose: Glycogen Synthase 1 (phospho Ser645) Polyclonal Antibody

Specificity: Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S645.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Glycogen Synthase 1 Phospho-Ser645

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Glycogen Synthase 1

Target: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Alternative Name: Glycogen Synthase 1

Background: Rabbit Anti-Glycogen Synthase 1 (phospho Ser645) Polyclonal Antibody,GYS1, GYS, Glycogen [starch] synthase, muscle,The glycogen synthase 1 encoded by GYS1 catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in GYS1 are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for GYS1.,Glycogen [starch] synthase muscle

Molecular Weight: observerd band 83kDa

Gene ID: 2997

UniProt: P13807

Pathways: PI3K-Akt Signaling, AMPK Signaling, Cellular Glucan Metabolic Process