GP5 antibody (Internal Region)

Catalog No. ABIN7218678

The Rabbit Polyclonal anti-GP5 antibody is suitable to detect GP5 in samples from Mouse, Human and Rat. It has been validated for WB, FACS, IHC, ELISA and IF.

Quick Overview for GP5 antibody (Internal Region) (ABIN7218678)

Target: GP5 (Glycoprotein V (Platelet) (GP5))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GP5 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-GP5 Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-CD42d Polyclonal Antibody

Specificity: CD42d Polyclonal Antibody detects endogenous levels of CD42d protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CD42d

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC: 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GP5

Target: GP5 (Glycoprotein V (Platelet) (GP5))

Alternative Name: CD42d

Background: GP5, Platelet glycoprotein V, GPV, Glycoprotein 5, CD42dHuman platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF, MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA, MIM 606672) and a beta chain (GP1BB, MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9, MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al. 1998 [PubMed: 9616133]).

Molecular Weight: 62kD

Gene ID: 2814

UniProt: P40197