GUCY1B2 antibody (N-Term)

Catalog No. ABIN7221398

The Rabbit Polyclonal anti-GUCY1B2 antibody is suitable to detect GUCY1B2 in samples from Human, Mouse and Rat. It has been validated for IHC, ELISA and IF.

Quick Overview for GUCY1B2 antibody (N-Term) (ABIN7221398)

Target: GUCY1B2 (Guanylate Cyclase 1, Soluble, beta 2 (GUCY1B2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCY1B2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-GUCY1B2 Antibody

Binding Specificity: N-Term

Purpose: Rabbit Anti-GCS-β-2 Polyclonal Antibody

Specificity: GCS-β-2 Polyclonal Antibody detects endogenous levels of GCS-β-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human GCS-beta-2

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GUCY1B2

Target: GUCY1B2 (Guanylate Cyclase 1, Soluble, beta 2 (GUCY1B2))

Alternative Name: GCS-beta-2

Background: GUCY1B2, Guanylate cyclase soluble subunit beta-2, GCS-beta-2Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide. Unlike other guanylyl cyclases, GUCY1B2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation.

Molecular Weight: 70kD

Gene ID: 2974

UniProt: O75343