HES5 antibody (AA 10-90)

Catalog No. ABIN7228890

The Rabbit Polyclonal anti-HES5 antibody is suitable to detect HES5 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for HES5 antibody (AA 10-90) (ABIN7228890)

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HES5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HES5 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-HES5 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of HES5 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human HES5 protein at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for HES5

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Alternative Name: HES5

Background: Transcription factor HES-5, Class B basic helix-loop-helix protein 38, bHLHb38, Hairy and enhancer of split 5HES5 (Hes Family BHLH Transcription Factor 5) encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of HES5, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of HES5 have been associated with developmental diseases and cancer. HES5 is a Protein Coding gene. Diseases associated with HES5 include Valproate Embryopathy, Susceptibility To. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus.

Molecular Weight: 18kD

Gene ID: 388585

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation