Haptoglobin antibody (AA 300-360)

Catalog No. ABIN7228842

The Rabbit Polyclonal anti-Haptoglobin antibody (ABIN7228842) specifically detects Haptoglobin in IHC, ELISA and IF. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Haptoglobin antibody (AA 300-360) (ABIN7228842)

Target: Haptoglobin (HP)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Haptoglobin antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Haptoglobin Antibody

Binding Specificity: AA 300-360

Purpose: Rabbit Anti-Haptoglobin Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Haptoglobin

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human Haptoglobin protein at AA range: 300-360

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Haptoglobin

Target: Haptoglobin (HP)

Alternative Name: Haptoglobin

Background: Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chainHP encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in HP and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. HP has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to HP on chromosome 16. Multiple transcript variants encoding different isoforms have been found for HP.

Gene ID: 3240

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis