HRG antibody

Catalog No. ABIN7228966

The Rabbit Polyclonal anti-HRG antibody is suitable to detect HRG in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for HRG antibody (ABIN7228966)

Target: HRG (Histidine-Rich Glycoprotein (HRG))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRG antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HRG Antibody

Purpose: Rabbit Anti-HRG Polyclonal Antibody

Specificity: The antibody detects endogenous levels of HRG protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human HRG protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for HRG

Target: HRG (Histidine-Rich Glycoprotein (HRG))

Alternative Name: HRG

Background: Histidine-rich glycoprotein, Histidine-proline-rich glycoprotein, HPRGThis histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. Histidine Rich Glycoprotein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in HRG lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

Molecular Weight: 57kD

Gene ID: 3273

UniProt: P04196