IRGM antibody (AA 101-150)

Catalog No. ABIN7229186

The Rabbit Polyclonal anti-IRGM antibody is suitable to detect IRGM in samples from Human and Rat. It has been validated for WB and ELISA.

Quick Overview for IRGM antibody (AA 101-150) (ABIN7229186)

Target: IRGM (Immunity-Related GTPase Family, M (IRGM))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRGM antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IRGM Antibody

Binding Specificity: AA 101-150

Purpose: Rabbit Anti-IRGM Polyclonal Antibody

Specificity: The antibody detects endogenous levels of IRGM protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human IRGM protein at AA range: 101-150

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IRGM

Target: IRGM (Immunity-Related GTPase Family, M (IRGM))

Alternative Name: IRGM

Background: Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47IRGM encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of IRGM are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 19kD

Gene ID: 345611

UniProt: A1A4Y4