ICOS antibody (Internal Region)

Catalog No. ABIN7226680

The Rabbit Polyclonal anti-ICOS antibody is suitable to detect ICOS in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for ICOS antibody (Internal Region) (ABIN7226680)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICOS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-ICOS Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-ICOS Polyclonal Antibody

Specificity: ICOS Polyclonal Antibody detects endogenous levels of ICOS protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human ICOS

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC: 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Alternative Name: ICOS

Background: ICOS, AILIM, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278The protein encoded by ICOS (inducible T-cell costimulator) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Molecular Weight: 22kD

Gene ID: 29851

UniProt: Q9Y6W8

Pathways: Cancer Immune Checkpoints