ITPR1 antibody

Catalog No. ABIN7221926

The Rabbit Polyclonal anti-ITPR1 antibody is suitable to detect ITPR1 in samples from Human, Rat and Mouse. It has been validated for ELISA, IHC and IF.

Quick Overview for ITPR1 antibody (ABIN7221926)

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ITPR1 Antibody

Purpose: Rabbit Anti-IP3R-I Polyclonal Antibody

Specificity: IP3R-I Polyclonal Antibody detects endogenous levels of IP3R-I protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human IP3R-I around the non-phosphorylation site of S1598

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ITPR1

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Alternative Name: IP3R-I

Background: ITPR1, INSP3R1, Inositol 1, 4,5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptorITPR1 encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.

Gene ID: 3708

UniProt: Q14643

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma