ITGA6 antibody (Cleaved-Glu942)

Catalog No. ABIN7212522

This Rabbit Polyclonal antibody specifically detects ITGA6 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ITGA6 antibody (Cleaved-Glu942) (ABIN7212522)

Target: ITGA6 (Integrin, alpha 6 (ITGA6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ITGA6 Antibody

Binding Specificity: AA 900-980, Cleaved-Glu942

Purpose: Rabbit Anti-Cleaved-Integrin α6 LC (E942) Polyclonal Antibody

Specificity: Cleaved-Integrin α6 LC (E942) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α6 LC protein resulting from cleavage adjacent to E942.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Integrin alpha6 LC at AA range: 900-980

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ITGA6

Target: ITGA6 (Integrin, alpha 6 (ITGA6))

Alternative Name: Integrin alpha6 LC

Background: ITGA6, Integrin alpha-6, CD49 antigen-like family member F, VLA-6, CD antigen CD49fITGA6 encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.

Molecular Weight: 28kD

Gene ID: 3655

UniProt: P23229

Pathways: CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex