CD51 antibody (Cleaved-Lys889)

Catalog No. ABIN7212526

The Rabbit Polyclonal anti-CD51 antibody (ABIN7212526) specifically detects CD51 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CD51 antibody (Cleaved-Lys889) (ABIN7212526)

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD51 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CD51 Antibody

Binding Specificity: AA 810-890, Cleaved-Lys889

Purpose: Rabbit Anti-Cleaved-Integrin αV HC (K889) Polyclonal Antibody

Specificity: Cleaved-Integrin αV HC (K889) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin αV HC protein resulting from cleavage adjacent to K889.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Integrin alphaV HC at AA range: 810-890

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Alternative Name: Integrin alphaV HC

Background: ITGAV, MSK8, VNRA, Integrin alpha-V, Vitronectin receptor subunit alpha, CD antigen CD51The product of ITGAV belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

Molecular Weight: 95kD

Gene ID: 3685

UniProt: P06756

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex