IL2 Receptor beta antibody (pTyr364)

Catalog No. ABIN7221756

The Rabbit Polyclonal anti-IL2 Receptor beta antibody has been validated for WB, ELISA and IF. It is suitable to detect IL2 Receptor beta in samples from Mouse, Human and Rat.

Quick Overview for IL2 Receptor beta antibody (pTyr364) (ABIN7221756)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL2 Receptor beta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-IL2 Receptor beta Antibody

Binding Specificity: pTyr364

Purpose: IL-2Rβ (phospho Tyr364) Polyclonal Antibody

Specificity: Phospho-IL-2Rβ (Y364) Polyclonal Antibody detects endogenous levels of IL-2Rβ protein only when phosphorylated at Y364.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human IL-2Rbeta Phospho-Tyr364

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: IL-2Rbeta

Background: Rabbit Anti-IL-2Rβ (phospho Tyr364) Polyclonal Antibody,IL2RB, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, p75, CD antigen CD122,The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by IL2RB represents the beta subunit and is a type I membrane protein.,Interleukin-2 receptor subunit beta

Molecular Weight: observerd band 61kDa

Gene ID: 3560

UniProt: P14784

Pathways: JAK-STAT Signaling, Growth Factor Binding