IL-22 antibody (C-Term)

Catalog No. ABIN7226698

The Rabbit Polyclonal anti-IL-22 antibody is suitable to detect IL-22 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for IL-22 antibody (C-Term) (ABIN7226698)

Target: IL-22 (IL22) (Interleukin 22 (IL22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-22 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL-22 Antibody

Binding Specificity: C-Term

Purpose: Rabbit Anti-IL-22 Polyclonal Antibody

Specificity: IL-22 Polyclonal Antibody detects endogenous levels of IL-22 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human IL-22

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IL-22

Target: IL-22 (IL22) (Interleukin 22 (IL22))

Alternative Name: IL-22

Background: IL22, ILTIF, ZCYTO18, Interleukin-22, IL-22, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, IL-TIFIL-10-related T cell-derived inducible factor (IL-22, also known as IL-TIF) is a cytokine that was originally identified in mouse as an IL-9 inducible gene in T cells and mast cells and shows 22 % amino acid identity with IL-10. Additionally, IL-22 is induced by IL-9 in thymic lymphomas and by lectins in freshly isolated splenocytes. IL-22 is found in both the thymus and brain, which suggests that the role of this factor is not restricted to the immune system. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family. In contrast to IL-10, IL-22 does not inhibit the production of proinflammatory cytokines by monocytes in response to lipopolysaccharide nor does it impact IL-10 function on monocytes, but it has modest inhibitory effects on IL-4 production from Th2 T cells.

Molecular Weight: 22kD

Gene ID: 50616

UniProt: Q9GZX6