Inversin antibody

Catalog No. ABIN7229172

This Rabbit Polyclonal antibody specifically detects Inversin in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Inversin antibody (ABIN7229172)

Target: Inversin (INVS)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Inversin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Inversin Antibody

Purpose: Rabbit Anti-INVS Polyclonal Antibody

Specificity: The antibody detects endogenous levels of INVS protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human INVS protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Inversin

Target: Inversin (INVS)

Alternative Name: INVS

Background: Inversin, Inversion of embryo turning homolog, Nephrocystin-2INVS (Inversin) is a Protein Coding gene. Diseases associated with INVS include Nephronophthisis 2, Infantile and Nephronophthisis 16. Among its related pathways are Wnt Signaling Pathway and Pluripotency. INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in INVS have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for INVS.

Molecular Weight: 117kD

Gene ID: 27130

UniProt: Q9Y283