ITIH4 antibody (Cleaved-Arg661)

Catalog No. ABIN7221914

The Rabbit Polyclonal anti-ITIH4 antibody (ABIN7221914) specifically detects ITIH4 in IHC, ELISA and IF. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for ITIH4 antibody (Cleaved-Arg661) (ABIN7221914)

Target: ITIH4 (Inter alpha Globulin Inhibitor H4 (ITIH4))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITIH4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-ITIH4 Antibody

Binding Specificity: AA 590-670, Cleaved-Arg661

Purpose: Rabbit Anti-Cleaved-ITI-H4 70k (R661) Polyclonal Antibody

Specificity: Cleaved-ITI-H4 70k (R661) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H4 70k protein resulting from cleavage adjacent to R661.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human ITI-H4 70k at AA range: 590-670

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ITIH4

Target: ITIH4 (Inter alpha Globulin Inhibitor H4 (ITIH4))

Alternative Name: ITI-H4 70k

Background: ITIH4, IHRP, ITIHL1, PK120, Inter-alpha-trypsin inhibitor heavy chain H4, ITI heavy chain H4, ITI-HC4, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP, Plasma kallikrein sensitiveThe protein encoded by ITIH4 is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID: 3700

UniProt: Q14624

Pathways: Glycosaminoglycan Metabolic Process