KRT4 antibody (AA 200-260)

Catalog No. ABIN7228142

The Rabbit Polyclonal anti-KRT4 antibody is suitable to detect KRT4 in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for KRT4 antibody (AA 200-260) (ABIN7228142)

Target: KRT4 (Keratin 4 (KRT4))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRT4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KRT4 Antibody

Binding Specificity: AA 200-260

Purpose: Rabbit Anti-Cytokeratin 4 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Cytokeratin 4

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human Cytokeratin 4 protein at AA range: 200-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for KRT4

Target: KRT4 (Keratin 4 (KRT4))

Alternative Name: Cytokeratin 4

Background: Keratin, type II cytoskeletal 4, Cytokeratin-4, CK-4, Keratin-4, K4, Type-II keratin Kb4The protein encoded by KRT4 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. KRT4 (Keratin 4) is a Protein Coding gene. Diseases associated with KRT4 include White Sponge Nevus 1 and White Sponge Nevus Of Cannon, Krt4-Related. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization.

Molecular Weight: 57kD

UniProt: P19013