LRRK1 antibody (AA 330-410)

Catalog No. ABIN7225092

The Rabbit Polyclonal anti-LRRK1 antibody (ABIN7225092) specifically detects LRRK1 in ELISA, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for LRRK1 antibody (AA 330-410) (ABIN7225092)

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRK1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LRRK1 Antibody

Binding Specificity: AA 330-410

Purpose: LRRK1 Polyclonal Antibody

Specificity: LRRK1 Polyclonal Antibody detects endogenous levels of LRRK1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human LRRK1 at AA range: 330-410

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for LRRK1

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Alternative Name: LRRK1

Background: Rabbit Anti-LRRK1 Polyclonal Antibody,LRRK1, KIAA1790, Leucine-rich repeat serine/threonine-protein kinase 1,The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease.,Leucine-rich repeat serine threonine-protein kinase 1

Gene ID: 79705

UniProt: Q38SD2