LRRK1 antibody (AA 330-410)

Catalog No. ABIN7225092

The Rabbit Polyclonal anti-LRRK1 antibody (ABIN7225092) specifically detects LRRK1 in ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for LRRK1 antibody (AA 330-410) (ABIN7225092)

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-LRRK1 Antibody

Binding Specificity: AA 330-410

Purpose: Rabbit Anti-LRRK1 Polyclonal Antibody

Specificity: LRRK1 Polyclonal Antibody detects endogenous levels of LRRK1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human LRRK1 at AA range: 330-410

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LRRK1

Target: LRRK1 (Leucine-Rich Repeat Kinase 1 (LRRK1))

Alternative Name: LRRK1

Background: LRRK1, KIAA1790, Leucine-rich repeat serine/threonine-protein kinase 1The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease.

Gene ID: 79705

UniProt: Q38SD2