LRP11 antibody (AA 20-100)

Catalog No. ABIN7225474

This Rabbit Polyclonal antibody specifically detects LRP11 in WB and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for LRP11 antibody (AA 20-100) (ABIN7225474)

Target: LRP11 (Low Density Lipoprotein Receptor Related Protein 11 (LRP11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LRP11 Antibody

Binding Specificity: AA 20-100

Purpose: Rabbit Anti-LRP11 Polyclonal Antibody

Specificity: LRP11 Polyclonal Antibody detects endogenous levels of LRP11 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human LRP11 at AA range: 20-100

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LRP11

Target: LRP11 (Low Density Lipoprotein Receptor Related Protein 11 (LRP11))

Alternative Name: LRP11

Background: LRP11, Low-density lipoprotein receptor-related protein 11, LRP-11Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP11 (low density lipoprotein receptor-related protein 11), also known as MANSC3, is a 500 amino acid single-pass type I membrane protein that exists as two alternatively spliced isoforms. LRP11 is encoded by a gene located on human chromosome 6q25. Chromosome 6 contains 170 million base pairs and comprises nearly 6 % of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Molecular Weight: 50kD

Gene ID: 84918

UniProt: Q86VZ4