LRP1B antibody (AA 200-280)

Catalog No. ABIN7229444

This Rabbit Polyclonal antibody specifically detects LRP1B in IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for LRP1B antibody (AA 200-280) (ABIN7229444)

Target: LRP1B (Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP1B antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-LRP1B Antibody

Binding Specificity: AA 200-280

Purpose: Rabbit Anti-LRP1B Polyclonal Antibody

Specificity: The antibody detects endogenous levels of LRP1B protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human LRP1B protein at AA range: 200-280

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LRP1B

Target: LRP1B (Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B))

Alternative Name: LRP1B

Background: Low-density lipoprotein receptor-related protein 1B, LRP-1B, Low-density lipoprotein receptor-related protein-deleted in tumor, LRP-DITLRP1B is a putative tumor suppressor and a member of the low-density lipoprotein (LDL) receptor family. The LDL receptor family have roles related to clearance of extracellular ligand and are proposed to be involved in extracellular signal transduction. silencing and down-expression of LRP1B as been observed in renal cell carcinoma and thyroid cancer. Further Deletion of LRP1B has been associated with chemotherapy resistance in high-grade serous cancers.

Molecular Weight: 505kD

Gene ID: 53353

UniProt: Q9NZR2