MRGPRD antibody

Catalog No. ABIN7229754

The Rabbit Polyclonal anti-MRGPRD antibody (ABIN7229754) specifically detects MRGPRD in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MRGPRD antibody (ABIN7229754)

Target: MRGPRD (MAS-Related GPR, Member D (MRGPRD))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRD antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MRGPRD Antibody

Purpose: Rabbit Anti-MRGRD Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MRGRD protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MRGRD protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MRGPRD

Target: MRGPRD (MAS-Related GPR, Member D (MRGPRD))

Alternative Name: MRGRD

Background: Mas-related G-protein coupled receptor member D, Beta-alanine receptor, G-protein coupled receptor TGR7MRGPRD (MAS Related GPR Family Member D) is a Protein Coding gene. Among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

Molecular Weight: 35kD

Gene ID: 116512

UniProt: Q8TDS7