MRGPRX1 antibody (AA 240-320)

Catalog No. ABIN7220926

This Rabbit Polyclonal antibody specifically detects MRGPRX1 in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for MRGPRX1 antibody (AA 240-320) (ABIN7220926)

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MRGPRX1 Antibody

Binding Specificity: AA 240-320

Purpose: Rabbit Anti-MRGX1 Polyclonal Antibody

Specificity: MRGX1 Polyclonal Antibody detects endogenous levels of MRGX1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human MRGX1 at AA range: 240-320

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MRGPRX1

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Alternative Name: MRGX1

Background: MRGPRX1, MRGX1, SNSR3, SNSR4, Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4MRGPRX1 (MAS Related GPR Family Member X1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4. rphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22) (PubMed: 26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Molecular Weight: 36kD

Gene ID: 259249

UniProt: Q96LB2