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MED12 antibody (AA 580-660)

This Rabbit Polyclonal antibody specifically detects MED12 in ELISA and IHC (p). It exhibits reactivity toward Human.
Catalog No. ABIN7226190
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$322.23
$379.10
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Quick Overview for MED12 antibody (AA 580-660) (ABIN7226190)

Target

See all MED12 Antibodies
MED12 (Mediator Complex Subunit 12 (MED12))

Reactivity

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Human

Host

  • 39
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Rabbit

Clonality

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Polyclonal

Conjugate

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This MED12 antibody is un-conjugated

Application

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Binding Specificity

    • 15
    • 5
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    AA 580-660

    Purpose

    TRAP230 Polyclonal Antibody

    Specificity

    TRAP230 Polyclonal Antibody detects endogenous levels of TRAP230 protein.

    Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

    Immunogen

    Synthesized peptide derived from the Internal region of human TRAP230 at AA range: 580-660

    Isotype

    IgG
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

    Comment

    Primary Antibody

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • Target

    MED12 (Mediator Complex Subunit 12 (MED12))

    Alternative Name

    TRAP230

    Background

    Rabbit Anti-TRAP230 Polyclonal Antibody,MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230, Mediator of RNA polymerase II transcription subunit 12, Activator-recruited cofactor 240 kDa component, ARC240, CAG repeat protein 45, Mediator complex subunit 12, OPA-containing prote,The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1. MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by the gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.,Mediator of RNA polymerase II transcription subunit 12

    Gene ID

    9968

    UniProt

    Q93074

    Pathways

    Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Tube Formation
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