Mesp2 antibody (AA 220-300)

Catalog No. ABIN7229648

This Rabbit Polyclonal antibody specifically detects Mesp2 in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for Mesp2 antibody (AA 220-300) (ABIN7229648)

Target: Mesp2 (Mesoderm Posterior 2 Homolog (Mesp2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mesp2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-Mesp2 Antibody

Binding Specificity: AA 220-300

Purpose: Rabbit Anti-MESP2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MESP2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MESP2 protein at AA range: 220-300

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Mesp2

Target: Mesp2 (Mesoderm Posterior 2 Homolog (Mesp2))

Alternative Name: MESP2

Background: Mesoderm posterior protein 2, Class C basic helix-loop-helix protein 6, bHLHc6MESP2 (Mesoderm Posterior BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with MESP2 include Spondylocostal Dysostosis 2, Autosomal Recessive and Spondylocostal Dysostosis, Autosomal Recessive. Among its related pathways are Cardiac Progenitor Differentiation and Gene regulatory network modelling somitogenesis. MESP2 encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. MESP2 is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. MESP2 also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).

Molecular Weight: 43kD

Gene ID: 145873

UniProt: Q0VG99