MCPH1 antibody (AA 60-140)

Catalog No. ABIN7225086

The Rabbit Polyclonal anti-MCPH1 antibody is suitable to detect MCPH1 in samples from Human and Mouse. It has been validated for WB, ELISA and IHC (p).

Quick Overview for MCPH1 antibody (AA 60-140) (ABIN7225086)

Target: MCPH1 (Microcephalin 1 (MCPH1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCPH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MCPH1 Antibody

Binding Specificity: AA 60-140

Purpose: Microcephalin Polyclonal Antibody

Specificity: Microcephalin Polyclonal Antibody detects endogenous levels of Microcephalin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human Microcephalin at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for MCPH1

Target: MCPH1 (Microcephalin 1 (MCPH1))

Alternative Name: Microcephalin

Background: Rabbit Anti-Microcephalin Polyclonal Antibody,MCPH1, Microcephalin,MCPH1 (microcephalin 1) encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in MCPH1 have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.,Microcephalin

Molecular Weight: observerd band 93kDa

Gene ID: 79648

UniProt: Q8NEM0

Pathways: Stem Cell Maintenance