MAP3K14 antibody (AA 90-170)

Catalog No. ABIN7229494

The Rabbit Polyclonal anti-MAP3K14 antibody has been validated for WB and ELISA. It is suitable to detect MAP3K14 in samples from Human.

Quick Overview for MAP3K14 antibody (AA 90-170) (ABIN7229494)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAP3K14 Antibody

Binding Specificity: AA 90-170

Purpose: M3K14 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of M3K14 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human M3K14 protein at AA range: 90-170

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: M3K14

Background: Rabbit Anti-M3K14 Polyclonal Antibody,Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK,MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. MAP3K14 is a Protein Coding gene. Diseases associated with MAP3K14 include Nik Deficiency. Among its related pathways are 4-1BB Pathway and RANK Signaling in Osteoclasts.,M3K14

Molecular Weight: observerd band 104kDa

Gene ID: 9020

UniProt: Q99558

Pathways: NF-kappaB Signaling, TCR Signaling