MAP4K5 antibody (AA 300-380)

Catalog No. ABIN7229500

The Rabbit Polyclonal anti-MAP4K5 antibody is suitable to detect MAP4K5 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for MAP4K5 antibody (AA 300-380) (ABIN7229500)

Target: MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAP4K5 Antibody

Binding Specificity: AA 300-380

Purpose: Rabbit Anti-M4K5 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of M4K5 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human M4K5 protein at AA range: 300-380

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MAP4K5

Target: MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5))

Alternative Name: M4K5

Background: Mitogen-activated protein kinase kinase kinase kinase 5, Kinase homologous to SPS1/STE20, KHS, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5) encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for MAP4K5. MAP4K5 is a Protein Coding gene. Diseases associated with MAP4K5 include Dysgraphia and Writing Disorder. Among its related pathways are TGF-Beta Pathway and Angiopoietin Like Protein 8 Regulatory Pathway.

Molecular Weight: 93kD

Gene ID: 11183

UniProt: Q9Y4K4