MYH11 antibody

Catalog No. ABIN7229826

The Rabbit Polyclonal anti-MYH11 antibody is suitable to detect MYH11 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for MYH11 antibody (ABIN7229826)

Target: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYH11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MYH11 Antibody

Purpose: MYH11 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MYH11 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human MYH11 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for MYH11

Target: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Alternative Name: MYH11

Background: Rabbit Anti-MYH11 Polyclonal Antibody,Myosin-11, Myosin heavy chain 11, Myosin heavy chain, smooth muscle isoform, SMMHC,Myosin Heavy Chain 11 encoded by MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.,MYH11

Molecular Weight: observerd band 216kDa

Gene ID: 4629

UniProt: P35749