NCKIPSD antibody

Catalog No. ABIN7231502

The Rabbit Polyclonal anti-NCKIPSD antibody (ABIN7231502) specifically detects NCKIPSD in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for NCKIPSD antibody (ABIN7231502)

Target: NCKIPSD (NCK Interacting Protein with SH3 Domain (NCKIPSD))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCKIPSD antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NCKIPSD Antibody

Purpose: Rabbit Anti-SPN90 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SPN90 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SPN90 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NCKIPSD

Target: NCKIPSD (NCK Interacting Protein with SH3 Domain (NCKIPSD))

Alternative Name: SPN90

Background: NCK-interacting protein with SH3 domain, 54 kDa VacA-interacting protein, 54 kDa vimentin-interacting protein, VIP54, 90 kDa SH3 protein interacting with Nck, AF3p21, Dia-interacting protein 1, DIP-1, Diaphanous protein-interacting protein, SH3 adapter protein SPIN90, WASP-interacting SH3-domain protein, WISH, Wiskott-Aldrich syndrome protein-interacting proteinThe protein encoded by NCKIPSD (NCK Interacting Protein With SH3 Domain) is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. NCKIPSD is involved in therapy-related leukemia by a chromosomal translocation t(3,11)(p21,q23) that involves NCKIPSD and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of NCKIPSD.

Molecular Weight: 79kD

Gene ID: 51517

UniProt: Q9NZQ3

Pathways: Protein targeting to Nucleus