NDE1 antibody (AA 270-350)

Catalog No. ABIN7229926

The Rabbit Polyclonal anti-NDE1 antibody (ABIN7229926) specifically detects NDE1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NDE1 antibody (AA 270-350) (ABIN7229926)

Target: NDE1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDE1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NDE1 Antibody

Binding Specificity: AA 270-350

Purpose: Rabbit Anti-NDE1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NDE1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human NDE1 protein at AA range: 270-350

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NDE1

Target: NDE1

Alternative Name: NDE1

Background: Nuclear distribution protein nudE homolog 1, NudENDE1 (NudE Neurodevelopment Protein 1) encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic.

Molecular Weight: 38kD

Gene ID: 54820

UniProt: Q9NXR1