NBR1 antibody

Catalog No. ABIN7212362

The Mouse Monoclonal anti-NBR1 antibody is suitable to detect NBR1 in samples from Human, Mouse and Rat. It has been validated for IF and IHC (p).

Quick Overview for NBR1 antibody (ABIN7212362)

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This NBR1 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7C3

Product Details anti-NBR1 Antibody

Purpose: NBR1 Mouse Monoclonal Antibody (7C3)

Specificity: The antibody detects endogenous NBR1 protein.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogen: Recombinant Protein of NBR1

Isotype: IgG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:50-1:200).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Alternative Name: NBR1

Background: Mouse Anti-NBR1 Mouse Monoclonal Antibody (7C3),Next to BRCA1 gene 1 protein, Cell migration-inducing gene 19 protein, Membrane component chromosome 17 surface marker 2, Neighbor of BRCA1 gene 1 protein, Protein 1A1-3B,The protein encoded by NBR1 (NBR1, autophagy cargo receptor) was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. NBR1 is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of NBR1 results in multiple transcript variants.,Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)

Molecular Weight: observerd band 120kDa

Gene ID: 4077

UniProt: Q14596

Pathways: Autophagy