UNC5B antibody (AA 350-430)

Catalog No. ABIN7232040

The Rabbit Polyclonal anti-UNC5B antibody is suitable to detect UNC5B in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for UNC5B antibody (AA 350-430) (ABIN7232040)

Target: UNC5B (Netrin receptor UNC5B (UNC5B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC5B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UNC5B Antibody

Binding Specificity: AA 350-430

Purpose: Rabbit Anti-UNC5B Polyclonal Antibody

Specificity: The antibody detects endogenous levels of UNC5B protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human UNC5B protein at AA range: 350-430

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for UNC5B

Target: UNC5B (Netrin receptor UNC5B (UNC5B))

Alternative Name: UNC5B

Background: Netrin receptor UNC5B, Protein unc-5 homolog 2, Protein unc-5 homolog B, p53-regulated receptor for death and life protein 1, p53RDL1UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Among its related pathways are Netrin-1 signaling and Netrin Signaling. UNC5B encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for UNC5B.

Molecular Weight: 103kD

Gene ID: 219699

UniProt: Q8IZJ1