Neurexin 1 antibody (AA 480-560)

Catalog No. ABIN7225960

The Rabbit Polyclonal anti-Neurexin 1 antibody is suitable to detect Neurexin 1 in samples from Human, Rat and Mouse. It has been validated for WB and IHC.

Quick Overview for Neurexin 1 antibody (AA 480-560) (ABIN7225960)

Target: Neurexin 1 (NRXN1)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurexin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Neurexin 1 Antibody

Binding Specificity: AA 480-560

Purpose: Rabbit Anti-Neurexin I Polyclonal Antibody

Specificity: Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Neurexin I at AA range: 480-560

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neurexin 1

Target: Neurexin 1 (NRXN1)

Alternative Name: Neurexin I

Background: NRXN1, KIAA0578, Neurexin-1-alpha, Neurexin I-alphaNRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Molecular Weight: 150kD

Gene ID: 9378

UniProt: Q9ULB1

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development