NRARP antibody

Catalog No. ABIN7230124

The Rabbit Polyclonal anti-NRARP antibody is suitable to detect NRARP in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for NRARP antibody (ABIN7230124)

Target: NRARP (NOTCH-Regulated Ankyrin Repeat Protein (NRARP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRARP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NRARP Antibody

Purpose: Rabbit Anti-NRARP Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NRARP protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human NRARP protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NRARP

Target: NRARP (NOTCH-Regulated Ankyrin Repeat Protein (NRARP))

Alternative Name: NRARP

Background: Notch-regulated ankyrin repeat-containing proteinNRARP (NOTCH Regulated Ankyrin Repeat Protein) is a Protein Coding gene. Among its related pathways are Notch signaling pathway (KEGG). Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).

Molecular Weight: 12kD

Gene ID: 441478

UniProt: Q7Z6K4