NUP93 antibody (AA 190-270)

Catalog No. ABIN7226068

The Rabbit Polyclonal anti-NUP93 antibody (ABIN7226068) specifically detects NUP93 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for NUP93 antibody (AA 190-270) (ABIN7226068)

Target: NUP93 (Nucleoporin 93kDa (NUP93))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUP93 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NUP93 Antibody

Binding Specificity: AA 190-270

Purpose: Rabbit Anti-Nup93 Polyclonal Antibody

Specificity: Nup93 Polyclonal Antibody detects endogenous levels of Nup93 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Nup93 at AA range: 190-270

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NUP93

Target: NUP93 (Nucleoporin 93kDa (NUP93))

Alternative Name: Nup93

Background: NUP93, KIAA0095, Nuclear pore complex protein Nup93, 93 kDa nucleoporin, Nucleoporin Nup93The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup93 (nucleoporin 93) is the most abundant nucleoporin found per NPC, contributing over 10 % of the mass. It localizes to the nuclear side of the NPC, predominantly in the basket terminal ring area, and exists in a complex with Nup188, Nup53 and Nup205. This complex is crucial for NPC stability and proper assembly. Nup93 interacts directly with the Nup62 complex located at the center of the NPC and thus tethers the two subcomplexes. Nup93 is composed of a coiled-coil domain at its N-terminus and a C-terminal helical domain. Its proper function is essential for cell viability and normal NPC function.

Molecular Weight: 93kD

Gene ID: 9688

UniProt: Q8N1F7