ORC1 antibody (AA 300-380)

Catalog No. ABIN7216330

This Rabbit Polyclonal antibody specifically detects ORC1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ORC1 antibody (AA 300-380) (ABIN7216330)

Target: ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ORC1 Antibody

Binding Specificity: AA 300-380

Purpose: Rabbit Anti-ORC1 Polyclonal Antibody

Specificity: ORC1 Polyclonal Antibody detects endogenous levels of ORC1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human ORC1 at AA range: 300-380

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ORC1

Target: ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))

Alternative Name: ORC1

Background: ORC1, ORC1L, PARC1, Origin recognition complex subunit 1, Replication control protein 1ORC1 encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function, to reverse the process, deubiquityling enzymes remove ubiquitin. Origin recognition complex subunit 1 contains an OTU domain and binds Ubal (ubiquitin aldehyde), an active cysteine protease site is present in the OTU domain.

Molecular Weight: 100,120kD

Gene ID: 4998

UniProt: Q13415

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA