PAX3 and PAX7 Binding Protein 1 (PAXBP1) antibody

Catalog No. ABIN7228626

This Rabbit Polyclonal antibody specifically detects PAX3 and PAX7 Binding Protein 1 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for PAX3 and PAX7 Binding Protein 1 (PAXBP1) antibody (ABIN7228626)

Target: PAX3 and PAX7 Binding Protein 1 (PAXBP1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Product Details

Purpose: Rabbit Anti-GCFC1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of GCFC1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human GCFC1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: PAX3 and PAX7 Binding Protein 1 (PAXBP1)

Alternative Name: GCFC1

Background: PAX3- and PAX7-binding protein 1, GC-rich sequence DNA-binding factor 1PAXBP1 encodes the PAX3 And PAX7 Binding Protein 1 that may bind to GC-rich DNA sequences, which suggests its involvement in the regulation of transcription. Alternative splicing of this gene results in multiple transcript variants. Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of Lys-4 of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).

Molecular Weight: 100kD

Gene ID: 94104

UniProt: Q9Y5B6