PGLYRP2 antibody

Catalog No. ABIN7231698

The Rabbit Polyclonal anti-PGLYRP2 antibody (ABIN7231698) specifically detects PGLYRP2 in ELISA and WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PGLYRP2 antibody (ABIN7231698)

Target: PGLYRP2 (Peptidoglycan Recognition Protein 2 (PGLYRP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGLYRP2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-PGLYRP2 Antibody

Purpose: Rabbit Anti-TAGL Polyclonal Antibody

Specificity: The antibody detects endogenous levels of TAGL protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human TAGL protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PGLYRP2

Target: PGLYRP2 (Peptidoglycan Recognition Protein 2 (PGLYRP2))

Alternative Name: TAGL

Background: Transgelin, 22 kDa actin-binding protein, Protein WS3-10, Smooth muscle protein 22-alpha, SM22-alphaTAGLN encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

Molecular Weight: 22kD

Gene ID: 6876

UniProt: Q01995

Pathways: Activation of Innate immune Response, Glycosaminoglycan Metabolic Process