PGE Synthase antibody (Internal Region)

Catalog No. ABIN7216522

The Rabbit Polyclonal anti-PGE Synthase antibody (ABIN7216522) specifically detects PGE Synthase in ELISA, WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PGE Synthase antibody (Internal Region) (ABIN7216522)

Target: PGE Synthase

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGE Synthase antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PGE Synthase Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-PGE synthase Polyclonal Antibody

Specificity: PGE synthase Polyclonal Antibody detects endogenous levels of PGE synthase protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human PGE synthase

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PGE Synthase

Target: PGE Synthase

Background: PTGES, MGST1L1, MPGES1, PGES, PIG12, Prostaglandin E synthase, Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 proteinProstaglandin E synthase encoded by PTGES is a glutathione-dependent prostaglandin E synthase. The expression of PTGES has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that PTGES may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Molecular Weight: 17kD

Gene ID: 9536

UniProt: O14684