PIGC antibody (AA 170-250)

Catalog No. ABIN7230640

This Rabbit Polyclonal antibody specifically detects PIGC in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PIGC antibody (AA 170-250) (ABIN7230640)

Target: PIGC (Phosphatidylinositol Glycan C (PIGC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIGC antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-PIGC Antibody

Binding Specificity: AA 170-250

Purpose: Rabbit Anti-PIGC Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PIGC protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PIGC protein at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PIGC

Target: PIGC (Phosphatidylinositol Glycan C (PIGC))

Alternative Name: PIGC

Background: Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, Phosphatidylinositol-glycan biosynthesis class C protein, PIG-CPIGC (Phosphatidylinositol Glycan Anchor Biosynthesis Class C) is a Protein Coding gene. Diseases associated with PIGC include Autosomal Recessive Non-Syndromic Intellectual Disability and Lassa Fever. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and Metabolism. PIGC encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for PIGC. A pseudogene on chromosome 11 has also been characterized.

Molecular Weight: 32kD

Gene ID: 5279

UniProt: Q92535

Pathways: Inositol Metabolic Process