PDE5A antibody

Catalog No. ABIN7230560

This Rabbit Polyclonal antibody specifically detects PDE5A in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for PDE5A antibody (ABIN7230560)

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE5A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PDE5A Antibody

Purpose: PDE5A Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PDE5A protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human PDE5A protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for PDE5A

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Alternative Name: PDE5A

Background: Rabbit Anti-PDE5A Polyclonal Antibody,cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE,PDE5A (Phosphodiesterase 5A) is a Protein Coding gene. Diseases associated with PDE5A include Priapism and Nonarteritic Anterior Ischemic Optic Neuropathy. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Platelet homeostasis. PDE5A encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of PDE5A results in three transcript variants encoding distinct isoforms.,PDE5A

Molecular Weight: observerd band 96kDa

Gene ID: 8654

UniProt: O76074

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling