Plastin 3 antibody (AA 180-260)

Catalog No. ABIN7230702

This Rabbit Polyclonal antibody specifically detects Plastin 3 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Plastin 3 antibody (AA 180-260) (ABIN7230702)

Target: Plastin 3 (PLS3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Plastin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Plastin 3 Antibody

Binding Specificity: AA 180-260

Purpose: Rabbit Anti-PLS3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PLS3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PLS3 protein at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Plastin 3

Target: Plastin 3 (PLS3)

Alternative Name: PLS3

Background: Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependent phospholipid scramblase 3May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.

Molecular Weight: 32kD

Gene ID: 57048

UniProt: Q9NRY6