PMS1 antibody (AA 410-490)

Catalog No. ABIN7216618

This Rabbit Polyclonal antibody specifically detects PMS1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for PMS1 antibody (AA 410-490) (ABIN7216618)

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PMS1 Antibody

Binding Specificity: AA 410-490

Purpose: Rabbit Anti-PMS1 Polyclonal Antibody

Specificity: PMS1 Polyclonal Antibody detects endogenous levels of PMS1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human PMS1 at AA range: 410-490

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PMS1

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Alternative Name: PMS1

Background: PMS1, PMSL1, PMS1 protein homolog 1, DNA mismatch repair protein PMS1PMS1 encodes a protein belonging to the DNA mismatch repair mutL/hexB family. PMS1 homolog 1, mismatch repair system component is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in PMS1 cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.

Molecular Weight: 105kD

Gene ID: 5378

UniProt: P54277