PVRL4 antibody (AA 290-370)

Catalog No. ABIN7225202

This Rabbit Polyclonal antibody specifically detects PVRL4 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for PVRL4 antibody (AA 290-370) (ABIN7225202)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PVRL4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PVRL4 Antibody

Binding Specificity: AA 290-370

Purpose: Rabbit Anti-Nectin 4 Polyclonal Antibody

Specificity: Nectin 4 Polyclonal Antibody detects endogenous levels of Nectin 4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Nectin 4 at AA range: 290-370

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Alternative Name: Nectin 4

Background: PVRL4, LNIR, PRR4, Poliovirus receptor-related protein 4, Ig superfamily receptor LNIR, Nectin-4NECTIN4 (nectin cell adhesion molecule 4) encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in NECTIN4 are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Molecular Weight: 55kD

Gene ID: 81607

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization