PCGF2 antibody

Catalog No. ABIN7230524

This Rabbit Polyclonal antibody specifically detects PCGF2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for PCGF2 antibody (ABIN7230524)

Target: PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCGF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PCGF2 Antibody

Purpose: Rabbit Anti-PCGF2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PCGF2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PCGF2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PCGF2

Target: PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))

Alternative Name: PCGF2

Background: Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144The protein encoded by PCGF2 gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

Molecular Weight: 37kD

Gene ID: 7703

UniProt: P35227

Pathways: Chromatin Binding