PKD2 antibody (pSer812)

Catalog No. ABIN7223162

This Rabbit Polyclonal antibody specifically detects PKD2 in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PKD2 antibody (pSer812) (ABIN7223162)

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PKD2 Antibody

Binding Specificity: pSer812

Purpose: Rabbit Anti-PKD2 (phospho Ser812) Polyclonal Antibody

Specificity: Phospho-PKD2 (S812) Polyclonal Antibody detects endogenous levels of PKD2S812.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human PKD2 Phospho-Ser812

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Alternative Name: PKD2

Background: PKD2, Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321PKD2 (polycystin 2, transient receptor potential cation channel) encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in PKD2 are associated with autosomal dominant polycystic kidney disease type 2.

Gene ID: 5311

UniProt: Q13563

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity