POLR2C antibody

Catalog No. ABIN7231148

This Rabbit Polyclonal antibody specifically detects POLR2C in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for POLR2C antibody (ABIN7231148)

Target: POLR2C (Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa (POLR2C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR2C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-POLR2C Antibody

Purpose: Rabbit Anti-RPB3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RPB3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RPB3 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for POLR2C

Target: POLR2C (Polymerase (RNA) II (DNA Directed) Polypeptide C, 33kDa (POLR2C))

Alternative Name: RPB3

Background: DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II 33 kDa polypeptide, DNA-directed RNA polymerase II subunit C, RPB31POLR2C encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. POLR2C (RNA Polymerase II Subunit C) is a Protein Coding gene. Diseases associated with POLR2C include Hiv-1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA damage_Role of Brca1 and Brca2 in DNA repair.

Molecular Weight: 30kD

Gene ID: 5432

UniProt: P19387

Pathways: Regulatory RNA Pathways