DYRK1B antibody (AA 35-130)

Catalog No. ABIN716501

The Rabbit Polyclonal anti-DYRK1B antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It is suitable to detect DYRK1B in samples from Human.

Quick Overview for DYRK1B antibody (AA 35-130) (ABIN716501)

Target: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-DYRK1B Antibody

Binding Specificity: AA 35-130

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MIRK/Dyrk1B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for DYRK1B

Target: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Alternative Name: Dyrk1b

Background:

Synonyms: MIRK, AOMS3, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Minibrain-related kinase, Mirk protein kinase, DYRK1B

Background: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Gene ID: 9149

UniProt: Q9Y463