PFN1 antibody

Catalog No. ABIN7230784

The Rabbit Polyclonal anti-PFN1 antibody (ABIN7230784) specifically detects PFN1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PFN1 antibody (ABIN7230784)

Target: PFN1 (Profilin 1 (PFN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PFN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PFN1 Antibody

Purpose: Rabbit Anti-PROF1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PROF1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PROF1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PFN1

Target: PFN1 (Profilin 1 (PFN1))

Alternative Name: PROF1

Background: Profilin-1, Epididymis tissue protein Li 184a, Profilin IBinds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.

Molecular Weight: 15kD

Gene ID: 5216

UniProt: P07737

Pathways: Regulation of Actin Filament Polymerization, Tube Formation, Maintenance of Protein Location