Prokineticin Receptor 1 antibody (AA 30-110)

Catalog No. ABIN7216600

This Rabbit Polyclonal antibody specifically detects Prokineticin Receptor 1 in ELISA, WB, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Prokineticin Receptor 1 antibody (AA 30-110) (ABIN7216600)

Target: Prokineticin Receptor 1 (PROKR1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prokineticin Receptor 1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Prokineticin Receptor 1 Antibody

Binding Specificity: AA 30-110

Purpose: Rabbit Anti-PKR1 Polyclonal Antibody

Specificity: PKR1 Polyclonal Antibody detects endogenous levels of PKR1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human PKR1 at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IF/ICC1:100-500,ELISA 1:5000-20000,IHC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Prokineticin Receptor 1

Target: Prokineticin Receptor 1 (PROKR1)

Alternative Name: PKR1

Background: PROKR1, GPR73, PKR1, Prokineticin receptor 1, PK-R1, G-protein coupled receptor 73, G-protein coupled receptor ZAQ, GPR73aPROKR1 encodes a member of the G-protein-coupled receptor family. prokineticin receptor 1 binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. Prokineticin receptor 1 is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. Prokineticin receptor 1 may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in PROKR1 may be associated with recurrent miscarriage.

Molecular Weight: 45kD

Gene ID: 10887

UniProt: Q8TCW9

Pathways: Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma